Early interleukin-1 receptor antagonist elevation in patients with acute myocardial infarction
| Autor: | Andrea D'Ambrosio, Germano Di Sciascio, Giuseppe Patti, Enrico Maria Zardi, Simona Mega, Domenico Maria Zardi, Giordano Dicuonzo, Gabriele Giorgi, Aldo Dobrina |
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| Přispěvatelé: | Patti, G, D'Ambrosio, A, Mega, S, Giorgi, G, Zardi, Em, Zardi, Dm, Dicuonzo, G, Dobrina, Aldo, DI SCIASCIO, G. |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Sialoglycoproteins Myocardial Infarction Infarction Chest pain Sensitivity and Specificity Angina Necrosis Internal medicine Infiammazione Troponin I Interleuchina1Ra Marker infartuale medicine Humans cardiovascular diseases Myocardial infarction Aged biology business.industry Myocardium Middle Aged medicine.disease Surgery Interleukin 1 Receptor Antagonist Protein Interleukin 1 receptor antagonist biology.protein Cardiology Creatine kinase Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Journal of the American College of Cardiology. 43(1) |
| ISSN: | 0735-1097 |
| Popis: | Objectives We sought to evaluate interleukin-1 receptor antagonist (IL-1Ra) levels in patients with ST-segment elevation acute myocardial infarction (AMI) upon emergency department (ED) admission in order to assess the sensitivity of such a determination by comparison with common markers of myocardial necrosis. Background Inflammatory markers are elevated in patients with unstable coronary syndromes, but IL-1Ra levels during the early phases of AMI have not been previously investigated. Methods Levels of IL-1Ra were measured in 44 consecutive patients with AMI and compared with creatine kinase (CK), CK-MB, troponin I, myoglobin, and C-reactive protein (CRP). Results Upon admission, 82% of patients had elevated (>230 pg/ml) IL-1Ra levels, compared with 41% of patients with raised CK (p = 0.001), CK-MB (45%, p = 0.002), troponin I (57%, p = 0.027), myoglobin (48%, p = 0.004), and CRP (57%, p = 0.019) levels. The IL-1Ra values were significantly higher in patients with heralded AMI than in those without pre-infarction angina (671 vs. 320 pg/ml, p = 0.013). The sensitivity of IL-1Ra determination increased to 86% when chest pain duration was ≤3 h and to 91% if heralded infarction occurred. Conclusions Our study indicates that, unlike markers of necrosis, an increase of IL-1Ra levels occurs early in patients with AMI, is more significant in those with heralded infarction and symptom onset ≤3 h, and precedes the release of markers of necrosis. Thus, IL-1Ra determination may be an important early adjuvant toward the diagnosis of AMI in the ED. |
| Databáze: | OpenAIRE |
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