Haplotype-Based Case–Control Study of the Human CYP11B2 Gene and Essential Hypertension in Yi and Hani Minorities of China
| Autor: | Shengjie Nie, Chunjie Xiao, Weihua Shou, Zhaoping Yue, Bifeng Chen |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aldosterone synthase China medicine.medical_specialty Genotype Single-nucleotide polymorphism Biology Essential hypertension Polymorphism Single Nucleotide Biochemistry Asian People Gene Frequency Polymorphism (computer science) Internal medicine Genetics medicine Cytochrome P-450 CYP11B2 Humans Genetic Predisposition to Disease Molecular Biology Allele frequency Alleles Minority Groups Ecology Evolution Behavior and Systematics Polymorphism Genetic Haplotype Case-control study General Medicine Middle Aged Tag SNP medicine.disease Haplotypes Case-Control Studies Hypertension biology.protein Female |
| Zdroj: | Biochemical Genetics. 49:122-137 |
| ISSN: | 1573-4927 0006-2928 |
| Popis: | This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the K173R polymorphism were genotyped using the PCR-RFLP method. In the Hani minority, rs4536 was significantly associated with hypertension, after Bonferroni correction. H9 AGGC constructed by tag SNPs was significantly higher in hypertensives than in controls (P = 0.001). Further, we observed that haplotype AGGC remained significantly associated with male hypertension after adjustment for covariates (OR = 3.76, P = 0.002). In the Yi minority, it was found that the CYP11B2 gene was not significantly associated with hypertension. These results indicated that haplotype AGGC conferred an increased risk for hypertension in the Hani minority male. In addition, CYP11B2 may not be associated with hypertension in the Yi minority of China. |
| Databáze: | OpenAIRE |
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