Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
| Autor: | Maria Majdan, Arkadiusz Koszarny |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Anti-La Antibody
musculoskeletal diseases anti-Ro60 antibody Anti-nuclear antibody Immunology primary Sjögren’s syndrome Rheumatology Sicca symptoms stomatognathic system Sicca syndrome Immunology and Allergy Medicine biology business.industry Autoantibody eye diseases stomatognathic diseases biology.protein anti-SSA antibody Sjogren s Antibody primary sjögren’s syndrome business Case-Based Review Anti-SSA/Ro autoantibodies anti-Ro52 antibody |
| Zdroj: | Reumatologia Rheumatology, Vol 59, Iss 4, Pp 260-264 (2021) |
| ISSN: | 2084-9834 0034-6233 |
| Popis: | Sicca syndrome, which is typical for Sjögren’s syndrome (SS), is relatively often comorbid with other autoimmune diseases. The current classification criteria for SS published in 2016 include only anti-SSA (anti-Ro) autoantibody, while the latest literature proposes that anti-Ro60/anti-Ro52 autoantibody profiles should be used instead, as these two types of antibodies correlate with specific clinical symptoms and laboratory test findings. The paper presents the case of a 41-year-old woman suffering from primary Sjögren’s syndrome (pSS) and her three daughters, who were under observation for rheumatic disorders due to sicca symptoms, especially pSS, as well as a discussion on separate determination of anti-Ro60 and anti-Ro52 autoantibodies based on current literature in the PubMed database. When testing with antinuclear antibodies, the Ro60+Ro52+La+ autoantibody profile most closely matches for pSS. Further research is needed to find marker antibodies for SS and quantification methods. |
| Databáze: | OpenAIRE |
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