Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer
| Autor: | Vasyl Vasko, Motoyasu Saji, K. Narahara, Kyle Porter, C. Lu, David Jarjoura, Sheue-yann Cheng, Matthew D. Ringel, K. M. D. La Perle, Samantha K McCarty |
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| Rok vydání: | 2011 |
| Předmět: |
Adenoma
endocrine system Cancer Research medicine.medical_specialty Lung Neoplasms gelsolin endocrine system diseases Thyrotropin Biology Article Metastasis Thyroid hormone receptor beta Mice 03 medical and health sciences 0302 clinical medicine Thyroid-stimulating hormone Internal medicine Genetics medicine Animals Gene Knock-In Techniques Thyroid Neoplasms Molecular Biology Thyroid cancer PI3 Kinase 030304 developmental biology 0303 health sciences Thyroid hormone receptor Neovascularization Pathologic Carcinoma Thyroid p27 Thyroid Hormone Receptor Beta medicine.disease Mice Inbred C57BL medicine.anatomical_structure Endocrinology Tumor progression 030220 oncology & carcinogenesis embryonic structures Cancer research Proto-Oncogene Proteins c-akt |
| Zdroj: | Oncogene |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/onc.2011.136 |
| Popis: | Akt activation is common in progressive thyroid cancer. In breast cancer, Akt1 induces primary cancer growth, but is reported to inhibit metastasis in vivo in several model systems. In contrast, clinical and in vitro studies suggest a metastasis-promoting role for Akt1 in thyroid cancer. The goal of this study was to determine the functional role of Akt1 in thyroid cancer growth and metastatic progression in vivo using thyroid hormone receptor (TR) β(PV/PV) knock-in (PV) mice, which develop metastatic thyroid cancer. We crossed Akt1(-/-) and PV mice and compared tumor development, local progression, metastasis and histology in TRβ(PV/PV)/Akt1(+/+) (PVPV-Akt1WT) and TRβ(PV/PV)/Akt1(-/-) (PVPV-Akt1KO) mice. Mice were killed at 3, 6, 9, 12 and 15 months; necropsy was performed and serum thyroid stimulating hormone (TSH) was measured. Thyroid hyperplasia occurred in both groups beginning at 3 months; the thyroid size was greater in the PVPV-Akt1WT mice (P |
| Databáze: | OpenAIRE |
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