Drusen-like Deposits in Young Adults Diagnosed With Systemic Lupus Erythematosus
| Autor: | Alessandro Invernizzi, Gabriella Moroni, Laura Dell'Arti, Gaia Leone, Daniela Galimberti, Aniruddha Agarwal, Alessandro Santaniello, Francesco Viola, Elena Garoli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent genetic structures Fundus Oculi Retinal Drusen Drusen Fundus (eye) Retina Young Adult 03 medical and health sciences 0302 clinical medicine immune system diseases Ophthalmology Photography medicine Humans Lupus Erythematosus Systemic Fluorescein Angiography Young adult skin and connective tissue diseases Retrospective Studies 030203 arthritis & rheumatology Lupus erythematosus medicine.diagnostic_test Choroid business.industry Fundus photography Reproducibility of Results Glomerulonephritis Retrospective cohort study Middle Aged medicine.disease Fluorescein angiography eye diseases Cross-Sectional Studies Italy 030221 ophthalmology & optometry Female sense organs business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | American Journal of Ophthalmology. 175:68-76 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2016.11.014 |
| Popis: | To determine the prevalence of drusen-like deposits (DLDs) and choroidal changes in patients with systemic lupus erythematosus (SLE), with or without glomerulonephritis; and to correlate ocular findings with systemic features.Case-control study.Sixty patients with SLE (age, 18-55 years; 30 with and 30 without SLE-related glomerulonephritis) and 60 age- and sex-matched healthy controls were enrolled. All patients underwent noninvasive multimodal imaging that included fundus photography, near-infrared reflectance, blue autofluorescence, blue reflectance, and spectral-domain optical coherence tomography (SDOCT). Images were analyzed for the prevalence of DLDs. Distribution, size, and number of DLDs were measured. Correlations between ocular findings and systemic features were analyzed. Subfoveal choroidal thickness (SCT) was measured using the SDOCT.Drusen-like deposits were detected in 40% of SLE subjects and 3.33% of controls (P.0001). Compared with other techniques, SDOCT detected the largest number of affected subjects. In eyes with DLDs, small, medium, and large lesions were found in 75%, 50%, and 42% of cases, respectively. Drusen-like deposits were located in the nasal, temporal, inferior, superior, and central regions of the posterior pole in 83%, 75%, 67%, 54%, and 25% of eyes, respectively. The prevalence of DLDs in patients with SLE was similar regardless of renal involvement, but patients with glomerulonephritis had more DLDs per eye, larger deposits, and DLDs in3 quadrants (P.001, P = .03, P = .009, respectively). Subfoveal choroidal thickness was greater in patients with SLE (P = .002).Drusen-like deposits in patients with SLE were independent of renal disease and were best detected with SDOCT. Lupus-related glomerulonephritis was associated with more fundus abnormalities and a screening SDOCT should be considered in all patients with SLE. Drusen-like deposits in the absence of glomerulonephritis may support the recent proposal that complement alteration is the primary cause of these lesions. |
| Databáze: | OpenAIRE |
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