IL-2–induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation
| Autor: | Claire W. Hallahan, Joseph W. Adelsberger, Dean Follmann, Richard T. Davey, Julia A. Metcalf, Irini Sereti, H. Clifford Lane, Kara B Anthony, Richard A. Lempicki, Hector Martinez-Wilson, Joseph A. Kovacs |
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| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Interleukin 2 medicine.medical_specialty Anti-HIV Agents T-Lymphocytes T cell Immunology HIV Infections Biology Lymphocyte Activation Biochemistry Cohort Studies chemistry.chemical_compound Aldesleukin Internal medicine medicine Humans IL-2 receptor Cell Biology Hematology CD4 Lymphocyte Count medicine.anatomical_structure Endocrinology chemistry Interleukin-2 Viral load Intracellular Ex vivo Bromodeoxyuridine medicine.drug |
| Zdroj: | Blood. 104:775-780 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2003-12-4355 |
| Popis: | Administration of interleukin 2 (IL-2) leads to selective and sustained CD4+ T-cell expansions in patients infected with HIV. It has been hypothesized that persistent CD4+ T-cell proliferation is the primary mechanism maintaining these expansions. T-cell proliferation was studied by ex vivo bromodeoxyuridine (BrdU) incorporation and intracellular Ki67 staining in HIV-infected patients treated with antiretroviral therapy (ART) with or without IL-2. In contrast to the tested hypothesis, HIV-infected patients treated with IL-2 had lower CD4+ T-cell proliferation compared to patients treated with ART alone. Independently of viral load changes, administration of IL-2 led to a decrease in basal CD4+ T-cell proliferation. Total numbers of CD4+ T cells with naive and recall, but not effector, memory phenotype were increased. The degree of CD4+ T-cell expansion correlated with the decreases in proliferation and a strong association was seen between these decreases and the expansion of the CD4+/CD25+ subset. Intermittent IL-2 in HIV-infected patients leads to expansions of CD4+/CD25+ T cells with naive and recall memory phenotypes that strongly correlate with decreases in proliferation. These data suggest that decreased T-cell proliferation is central in the CD4+ T-cell expansions induced by IL-2. |
| Databáze: | OpenAIRE |
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