Correlation between Dose and Tumor Response in the Radiotherapy of Lung Cancer of Various Histological Types
| Autor: | Toshiyuki Kusuhara, Keiko Asada, Katsushi Watanabe, K Nishikawa, Kenji Koga |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Cell type Lung Neoplasms medicine.medical_treatment Urology Adenocarcinoma Tumor response Small-cell carcinoma Correlation Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Carcinoma Small Cell Lung cancer Aged business.industry Dose fractionation Radiotherapy Dosage General Medicine Middle Aged medicine.disease Radiography Radiation therapy Carcinoma Squamous Cell business |
| Zdroj: | Japanese Journal of Clinical Oncology. |
| ISSN: | 1465-3621 |
| DOI: | 10.1093/oxfordjournals.jjco.a038983 |
| Popis: | Correlation between dose and tumor response by cell types was determined in 50 patients with lung cancer in order to predict the possibility of further tumor regression. The TDF (time-dose-fractionation) concept was used as dose factor. The radiation source was a cobalt-60 gamma-ray or linear accelerator 10 MV X-ray. As a routine regime a fraction dose of 2 Gy five times per week was given to 39 of the 50 patients, but a dose of 2 Gy three times per week or of 1.5 Gy five times per week was given to seven and four patients, respectively. Radiation response was the best in small cell carcinoma and better in adenocarcinoma than in squamous cell carcinoma, showing a tumor regression rate of 50% or more in 90%, 80% and 58% of the patients, respectively. The correlation between tumor regression rate and TDF values was good in squamous cell carcinoma (r = 0.73) and small cell carcinoma (r = -0.72), but poor in adenocarcinoma (r = -0.10). These results suggest that in squamous cell carcinoma improvement of tumor regression can be expected by increasing TDF values, and in adenocarcinoma and small cell carcinoma the optimal TDF values are about 100 and 60 to 80, respectively. |
| Databáze: | OpenAIRE |
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