Effect of XlogP and Hansen Solubility Parameters on Small Molecule Modified Paclitaxel Anticancer Drug Conjugates Self-Assembled into Nanoparticles
| Autor: | Ting Zhong, Mei-Qi Xu, Zhan-Tao Li, Hui Li, Shuang Zhang, Yan-Li Hao, Xuan Zhang, Xiao-Chuan Duan, Xin Yao, Yang Guo, Xiu-Chai Zheng, Yi-Fan Yin |
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| Rok vydání: | 2018 |
| Předmět: |
Paclitaxel
Cell Survival Biomedical Engineering Pharmaceutical Science Nanoparticle Bioengineering Antineoplastic Agents Breast Neoplasms 02 engineering and technology 010402 general chemistry 01 natural sciences Self assembled Small Molecule Libraries chemistry.chemical_compound Humans health care economics and organizations Pharmacology Organic Chemistry technology industry and agriculture 021001 nanoscience & nanotechnology Small molecule Combinatorial chemistry Anticancer drug 0104 chemical sciences Hildebrand solubility parameter chemistry Solubility MCF-7 Cells Nanoparticles 0210 nano-technology Linker Hydrophobic and Hydrophilic Interactions Biotechnology Conjugate |
| Zdroj: | Bioconjugate chemistry. 29(2) |
| ISSN: | 1520-4812 |
| Popis: | Small molecule modified anticancer drug conjugates (SMMDCs) can self-assemble into nanoparticles (NPs) as therapeutic NP platforms for cancer treatment. Here we demonstrate that the XlogP and Hansen solubility parameters of paclitaxel (PTX) SMMDCs is essential for SMMDCs self-assembling into NPs. The amorphous state of PTX SMMDCs will also affect SMMDCs self-assembling into NPs. However, the antitumor activity of these PTX SMMDCs NPs decreased along with their XlogP values, indicating that a suitable XlogP value for designing the SMMDCs is important for self-assembling into NPs and for possessing antitumor activity. For higher level XlogP SMMDCs, a degradable linker should be considered in the design of SMMDCs to overcome the problem of lower antitumor activity. It is preferable that the hydrophilic groups in the SMMDCs should be present on the surface of self-assembling NPs. |
| Databáze: | OpenAIRE |
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