Real-life impact of uncontrolled severe asthma on mortality and healthcare use in adolescents and adults: findings from the retrospective, observational RESONANCE study in France
| Autor: | Nicolas Roche, Gilles Garcia, Alexandre de Larrard, Charlotte Cancalon, Stève Bénard, Vincent Perez, Aymeric Mahieu, Laurine Vieu, Pascal Demoly |
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| Přispěvatelé: | AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Paris-Saclay, stève consultants [Oullins], Sanofi Gentilly (Sanofi Gentilly), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Médecine de précision par intégration de données et inférence causale (PREMEDICAL), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), This work was supported by Sanofi-Aventis France |
| Rok vydání: | 2022 |
| Předmět: |
Adult
MESH: Adolescent MESH: Humans Adolescent MESH: Asthma Epidemiology MESH: Delivery of Health Care MESH: Adult MESH: Retrospective Studies General Medicine MESH: Cost of Illness [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Asthma MESH: France Cost of Illness Humans France Health economics Delivery of Health Care Retrospective Studies |
| Zdroj: | BMJ Open BMJ Open, 2022, 12 (8), pp.e060160. ⟨10.1136/bmjopen-2021-060160⟩ |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveTo characterise uncontrolled severe asthma and compare the disease burden with the general and asthmatic populations.DesignRetrospective observational study using a national sample of a French healthcare database (Echantillon Généraliste des Bénéficiaires (EGB)).SettingThe EGB, an anonymised permanent sample of health insurance databases, representing 1/97th of the French population.ParticipantsPatients (≥12 years) were selected in year 2014 and followed 2 years. A cohort of patients with uncontrolled severe asthma was defined using an algorithm based on peer-reviewed literature and Global Initiative for Asthma recommendations. Index date was the occurrence of the first marker of uncontrolled asthma. This cohort was matched with two control cohorts, general population and asthmatic controls, on baseline characteristics.Main outcomes measuresMortality, healthcare use and associated costs were studied in the 2 years of follow-up.ResultsAmong 467 716 individuals in the EGB, 16 588 patients with asthma were identified, including 739 (4.5%) with uncontrolled severe disease. The survival probability at 2 years for patients with uncontrolled severe asthma (92.0%) was lower than in the general population cohort (96.6%; relative risk of death: 2.35; 95% CI: 1.70 to 3.29; pConclusionsThis study demonstrates the huge burden of uncontrolled severe asthma in terms of mortality, morbidity and healthcare resource consumption compared with other patients with asthma and with the general population and emphasises the importance of appropriate management in this high-risk population. |
| Databáze: | OpenAIRE |
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