B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet
| Autor: | Qiuzhen Wang, Aiguo Ma, Ying Zheng, Xiuxia Han, Evert G. Schouten, Hui Liang, Ming-Ci Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty obesity body weight gain B vitamins Pyruvate Kinase Glutathione reductase Riboflavin Glucosephosphate Dehydrogenase 030204 cardiovascular system & hematology Diet High-Fat Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Genetics medicine Animals Rats Wistar Triglycerides Human Nutrition & Health Triglyceride Body Weight Humane Voeding & Gezondheid Vitamins Pyridoxine rats Cholesterol Glutathione Reductase 030104 developmental biology Endocrinology chemistry enzyme activities Vitamin B Complex Thiamine Anti-Obesity Agents Pyruvic acid Transketolase Niacin medicine.drug |
| Zdroj: | Current Medical Science, 38(1), 174-183 Current Medical Science 38 (2018) 1 |
| ISSN: | 2096-5230 |
| DOI: | 10.1007/s11596-018-1862-9 |
| Popis: | B vitamins are enzyme cofactors that play an important role in energy metabolism. The aim of this study was to elucidate whether B vitamin administration can reduce body weight (BW) gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet. Fifty rats were randomly assigned to one of the following five groups: control group (C), including rats fed on standard rat chow; four treatment groups (HO, HI, H2, and H3), in which rats were fed on a high-fat diet. Rats in the HI group were treated daily with 100 mg/kg BW thiamine (VB1), 100 mg/kg BW riboflavin (VB2), and 250 mg/kg BW niacin (VPP); rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine (VB6), 100 mg/kg BW cobalamin (VB12), and 5 mg/kg BW folate (FA); and rats in the H3 group were treated daily with all of the B vitamins administered to the HI and H2 groups. After 12 weeks, the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the HI and C groups, respectively, which were significantly less than the changes in the HO group (285.2±14.8 g, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink