Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance
| Autor: | Carlota Gudiol, Adaia Albasanz-Puig, Guillermo Cuervo, Jordi Carratalà |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty antibiotic resistance medicine.drug_class 030106 microbiology Antibiotics Population bloodstream infection Review sepsis Sepsis 03 medical and health sciences 0302 clinical medicine Antibiotic resistance cancer neutropenia Medicine 030212 general & internal medicine bacteremia Càncer education Intensive care medicine Cancer Inflammation lcsh:R5-920 education.field_of_study business.industry Septic shock Mortality rate Immunosupressive agents General Medicine medicine.disease Inflamació Bacteremia septic shock Immunosupressors lcsh:Medicine (General) business |
| Zdroj: | Frontiers in Medicine Frontiers in Medicine, Vol 8 (2021) Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 2296-858X |
| DOI: | 10.3389/fmed.2021.636547 |
| Popis: | Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starting adequate empirical antibiotic therapy can lead to poor outcomes. In this review, we aim to address: (1) the mechanisms involved in the development of sepsis and septic shock in these patients; (2) the risk factors associated with a worse prognosis; (3) the impact of adequate initial empirical antibiotic therapy given the current era of widespread antimicrobial resistance; and (4) the optimal management of sepsis, including adequate and early source control of infection, optimized antibiotic use based on the pharmacokinetic and pharmacodynamics changes in these patients, and the role of the new available antibiotics. |
| Databáze: | OpenAIRE |
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