An Optimal Method for Experimental Provocation of Polymorphic Light Eruption
| Autor: | John L.M. Hawk, Susan L. Walker, Chantalle B. van de Pas, Antony R. Young |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Clinical Trials as Topic
medicine.medical_specialty Erythema Ultraviolet Rays business.industry Provocation test Outcome measures Dermatology General Medicine Radiation Dosage medicine.disease Surgery Ultraviolet B radiation Predictive Value of Tests medicine Humans Polymorphic light eruption Photosensitivity Disorders medicine.symptom Polymorphous light eruption business Skin Skin Tests |
| Zdroj: | Archives of Dermatology. 140 |
| ISSN: | 0003-987X |
| Popis: | Background There is controversy about the best method to induce polymorphic light eruption (PLE) experimentally. Objectives To review articles on PLE induction and design a UV radiation protocol that improves success rates with clinically relevant doses of environmentallyrelevant solar-simulated radiation (SSR). Design and Setting All articles on the experimental provocation of PLE published since 1980 were reviewed. Photoprovocation of lesions was studied in 25 PLE patients.The 24-hour minimal erythemal dose (MED) of SSR was determined. Thereafter, six 4 × 4-cm adjacent sites on previously affected and previously unaffectedskin were exposed to 0.25, 0.5, 0.75, 1.0, 1.25, 1.5 MED of SSR for 3 to 4 consecutive days. The study periodwas autumn to spring in London, England(51° north latitude). Main Outcome Measures Relationship between PLE induction and biological and physical exposure parameters. Conclusions The review shows that fractionated erythemally effective UV-A exposures were more successful than single-sunburning UV-B doses. Photoprovocation ofPLE was successful in 68% of patients after 2 to 3 SSR exposures that were not necessarily erythemal. There was no difference in success rate betweenpreviously affected and previously unaffected skin. Our data indicate that PLE is more likely to be induced when the natural causes of the disease aresimulated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|