Multiparity, Brain Atrophy, and Cognitive Decline
| Autor: | Haejung Joung, Yu Kyeong Kim, Joon Hyung Jung, Gi Jung Jung, Dahyun Yi, Koung Mi Kang, Chul-Ho Sohn, Jun Ho Lee, Ga Won Lee, Min Soo Byun, Dong Young Lee, So Yeon Jeon, Seong A. Shin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty hippocampus Cognitive Neuroscience childbirth lcsh:RC321-571 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrophy Internal medicine medicine Dementia multiparity Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research medicine.diagnostic_test business.industry beta-amyloid Confounding neurodegeneration Neuropsychology Magnetic resonance imaging medicine.disease Hyperintensity 030104 developmental biology chemistry Cardiology Pittsburgh compound B business Alzheimer’s disease 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 12 (2020) |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2020.00159 |
| Popis: | Background Multiparity - grand multiparity (i.e., five or more childbirths) in particular - has been reported to have an association with increased risk of Alzheimer's disease (AD) dementia or related cognitive decline in women. However, the pathological links underlying this relationship are still unknown. This study was conducted to examine the relationships of multiparity with cerebral amyloid-beta (Aβ) deposition, brain atrophy, and white matter hyperintensities (WMHs). Methods In this study, total of 237 older women with 148 cognitively normal and 89 mild cognitive impairment from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) were included. Participants underwent clinical and neuropsychological assessments in addition to 11C-labeled Pittsburgh Compound B positron emission tomography, and magnetic resonance imaging. The associations of parity with Aβ deposition, hippocampal volume, cortical volume, WMH volume and mini-mental status examination (MMSE) score were examined. Results Participants with grand multiparity showed significantly reduced adjusted hippocampal volume, spatial pattern of atrophy for recognition of AD volume and spatial pattern of atrophy for recognition of brain aging volume even after controlling for potential confounders. Furthermore, MMSE score was also significantly lower in this group. In contrast, grand multiparity did not show any association with global Aβ retention, Aβ positivity rate, or WMH volume, regardless of covariates. Conclusion Our findings suggest that grand multiparity contributes to cognitive decline or increased dementia risk in older women by aggravating amyloid-independent hippocampal or cortical atrophy. |
| Databáze: | OpenAIRE |
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