Metabolic formation and synthesis of 1-(3-chlorophenyl)-2-(4-hydroxyphenyl)-1-methyl-2-(2-pyridine)ethanol. A potential hypocholesteremic agent

Autor:	J. H. Burckhalter, L. E. Hewitt, Joseph E. Sinsheimer, D. R. Wade, E. Van den Eeckhout, D. W. Hansen, Y. Kido, John C. Drach
Rok vydání:	1976
Předmět:	Male Drug Time Factors Ethanol Pyridines Chemistry Anticholesteremic Agents Metabolite Urinary system media_common.quotation_subject Pharmacology Rats Cholesterol blood chemistry.chemical_compound Cholesterol Biochemistry Drug Discovery Pyridine Animals Molecular Medicine media_common
Zdroj:	Journal of Medicinal Chemistry. 19:647-650
ISSN:	1520-4804 0022-2623
Popis:	1-(3-Chlorophenyl)-2-(4-hydroxphenyl)-1-methyl-2(2-pyridine)ethanol (8a) has been synthesized and found to be the major urinary metabolite following intraperitoneal administration of 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine)ethanol (1) to rats. This metabolite has a hypocholesteremic effect in rats similar to that of the parent drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2490efb05a6295e61b912de5a80a2 https://doi.org/10.1021/jm00227a014 Zobrazit plný text záznamu