Metabolic formation and synthesis of 1-(3-chlorophenyl)-2-(4-hydroxyphenyl)-1-methyl-2-(2-pyridine)ethanol. A potential hypocholesteremic agent
Autor: | J. H. Burckhalter, L. E. Hewitt, Joseph E. Sinsheimer, D. R. Wade, E. Van den Eeckhout, D. W. Hansen, Y. Kido, John C. Drach |
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Rok vydání: | 1976 |
Předmět: | |
Zdroj: | Journal of Medicinal Chemistry. 19:647-650 |
ISSN: | 1520-4804 0022-2623 |
Popis: | 1-(3-Chlorophenyl)-2-(4-hydroxphenyl)-1-methyl-2(2-pyridine)ethanol (8a) has been synthesized and found to be the major urinary metabolite following intraperitoneal administration of 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine)ethanol (1) to rats. This metabolite has a hypocholesteremic effect in rats similar to that of the parent drug. |
Databáze: | OpenAIRE |
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