Efficacy of mycophenolate mofetil in adult refractory auto-immune cytopenias: a single center preliminary study
| Autor: | Caroline Pinganaud, Marie Dreyfus, Gil Tchernia, Olivier Lambotte, Jean-François Delfraissy, Cécile Goujard, Rami Kotb, Catherine Trichet |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Evans syndrome Single Center Refractory Prednisone Internal medicine Humans Medicine Prospective cohort study Aged Autoantibodies Retrospective Studies Purpura Thrombocytopenic Idiopathic Cytopenia business.industry Retrospective cohort study Hematology General Medicine Middle Aged Mycophenolic Acid medicine.disease Thrombocytopenic purpura Surgery Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | European Journal of Haematology. 75:60-64 |
| ISSN: | 1600-0609 0902-4441 |
| Popis: | UNLABELLED Treatment of auto-immune cytopenia refractory to front line therapy with intravenous immunoglobulins and steroids is a matter of concern. We assessed the efficacy and safety of mycophenolate mofetil in a prospective open preliminary study. STUDY DESIGN Adult patients with steroid refractory auto-immune cytopenias were included. Mycophenolate mofetil (MMF) was added to treatment given at the time of inclusion, and efficacy was evaluated in term of improvement of platelet/haemoglobin levels and in term of reduction of previously given drugs, if any. All auto-immune thrombocytopenic purpura (AITP) patients had serologic assessment for associated auto-antibodies at the time of inclusion. Cytopenias associated with other auto-immune diseases, lymphoproliferative diseases or HIV infection were excluded. RESULTS From November 1999 through November 2003, 13 patients were included (nine AITP, three auto-immune haemolytic anaemia (AIHA), one Evans' syndrome; four males, nine females; age: 35-72 yr). For AITP patients, an overall response of 78% was observed. Retrospective analysis showed no significant difference between patients having a short disease duration ( |
| Databáze: | OpenAIRE |
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