Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: a randomized, placebo-controlled trial
| Autor: | Yi Chen, De-yu Fu, Yan-qiu Xu, Xiao-tao Feng, Teng Zhang, Wen-jian Wang, Yi Liu, Xiao-dong Fu, Yu Chen, Yan-ming He |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Ambulatory blood pressure Adolescent Population Placebo-controlled study Blood Pressure law.invention Young Adult Insulin resistance Randomized controlled trial law Internal medicine Humans Medicine education Aged Glycated Hemoglobin Metabolic Syndrome education.field_of_study Traditional medicine business.industry General Medicine Middle Aged medicine.disease Lipids Treatment Outcome Blood pressure Hypertension Homeostatic model assessment Female Metabolic syndrome business Drugs Chinese Herbal |
| Zdroj: | Journal of Integrative Medicine. 11:184-194 |
| ISSN: | 2095-4964 |
| DOI: | 10.3736/jintegrmed2013031 |
| Popis: | Background Patients with hypertension coupled with metabolic syndrome (MetS) are among the high risk population in cardiovascular and cerebrovascular diseases. To reduce the prevalence of cardiovascular and cerebrovascular diseases, it is essential to appropriately control blood pressure together with other cardiovascular risk factors. Objective The current study was designed to investigate the therapeutic effects on blood pressure, blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula, a compound traditional Chinese herbal medicine, in addition to routine treatment to hypertensive patients coupled with MetS. Design, setting, participants and interventions A total of 43 patients with hypertension coupled with MetS were recruited into this study. The enrolled patients were randomly divided into the Chinese herbal formula group (anti-hypertensive drugs plus Yiqi Huaju Formula, CHF) and the control group (anti-hypertensive drugs plus placebo). The CHF group enrolled 22 patients while the control group received 21 cases. Treatments were given for 12 weeks in both groups. Main outcome measures Parameters examined include 24-hour ambulatory blood pressure monitoring, body mass index, waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance (HOMA-IR), fasting glycosylated hemoglobin (HbA1c), fasting plasma glucose, 2-hour postprandial plasma glucose (PPG), fasting plasma insulin, serum lipid, etc. Results Compared with the control group, the CHF group had significant improvement ( P Conclusion This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors. The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention. Trial registration identifier This trial was registered in the Chinese Clinical Trial Registry with the identifier ChiCTR-TRC-11001633. |
| Databáze: | OpenAIRE |
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