Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?
| Autor: | Dagmar Hornung, Stefan Huttenlocher, Dirk Rades, Steven E. Schild, Oliver Blanck, Dorothea Fischer |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oncology
Adult medicine.medical_specialty Multivariate analysis medicine.medical_treatment Breast Neoplasms Radiosurgery Whole-brain radiotherapy Breast cancer Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Metastasis Freedom from new brain metastases Aged Retrospective Studies Univariate analysis Performance status business.industry Brain Neoplasms Research Cancer Retrospective cohort study Brain metastases Middle Aged medicine.disease Combined Modality Therapy Radiation therapy Radiology Nuclear Medicine and imaging Multivariate Analysis Female Cranial Irradiation business |
| Zdroj: | Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| DOI: | 10.1186/s13014-014-0267-6 |
| Popis: | Background An important issue in palliative radiation oncology is the whether whole-brain radiotherapy should be added to radiosurgery when treating a limited number of brain metastases. To optimize personalized treatment of cancer patients with brain metastases, the value of whole-brain radiotherapy should be described separately for each tumor entity. This study investigated the role of whole-brain radiotherapy added to radiosurgery in breast cancer patients. Methods Fifty-eight patients with 1–3 brain metastases from breast cancer were included in this retrospective study. Of these patients, 30 were treated with radiosurgery alone and 28 with radiosurgery plus whole-brain radiotherapy. Both groups were compared for local control of the irradiated metastases, freedom from new brain metastases and survival. Furthermore, eight additional factors were analyzed including dose of radiosurgery, age at radiotherapy, Eastern Cooperative Oncology Group (ECOG) performance score, number of brain metastases, maximum diameter of all brain metastases, site of brain metastases, extra-cranial metastases and the time from breast cancer diagnosis to radiotherapy. Results The treatment regimen had no significant impact on local control in the univariate analysis (p = 0.59). Age ≤59 years showed a trend towards improved local control on univariate (p = 0.066) and multivariate analysis (p = 0.07). On univariate analysis, radiosurgery plus whole-brain radiotherapy (p = 0.040) and ECOG 0–1 (p = 0.012) showed positive associations with freedom from new brain metastases. Both treatment regimen (p = 0.039) and performance status (p = 0.028) maintained significance on multivariate analysis. ECOG 0–1 was positively correlated with survival on univariate analysis (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|