Association of type 1 diabetes mellitus and autoimmune disorders in Brazilian children and adolescents
| Autor: | Larissa Siqueira Santos, Maria Betânia Pereira Toralles, Crésio Alves |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Immunoglobulin A
endocrine system medicine.medical_specialty endocrine system diseases type 1 diabetes Endocrinology Diabetes and Metabolism Autoimmunity 030209 endocrinology & metabolism Context (language use) Disease medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Thyroiditis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine 030212 general & internal medicine lcsh:RC799-869 Type 1 diabetes lcsh:RC648-665 biology business.industry nutritional and metabolic diseases medicine.disease Immunology thyroiditis biology.protein Pancreatitis Original Article lcsh:Diseases of the digestive system. Gastroenterology Antibody business celiac disease |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 20, Iss 3, Pp 381-386 (2016) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-8210 |
| DOI: | 10.4103/2230-8210.179994 |
| Popis: | Context: Type 1 diabetes mellitus (T1DM) is caused by an immune-mediated destruction of pancreatic beta cells. Other autoimmune diseases can be observed in association with T1DM. The screening for celiac disease (CD) and Hashimoto's thyroiditis is necessary due to the increased prevalence of these pathologies in T1DM patients. Aims: This study aimed to investigate the prevalence of autoimmune markers for pancreatitis, thyroiditis, and CD in racially admixtured children and adolescents with T1DM. Settings and Design: Cross-sectional clinic-based study. Methods: Seventy-one patients with T1DM (average: 11.6 ± 5.1 years). In all patients, the following antibodies were surveyed: Anti-glutamic acid decarboxylase (anti-GAD), immunoglobulin A (IgA) anti-transglutaminase (anti-tTG), Antithyroglobulin (AAT), anti-thyroid peroxidase (anti-TPO), and IgA. Statistical Analysis Used: The quantitative variables were expressed as a mean and standard deviation and the qualitative variables in contingency tables. Student's t -test and χ 2 tests were used to assess the differences between the groups. The level of significance was established as P Results: The prevalence of anti-GAD antibodies was 5.9%; anti-tTG IgA, 7.4%; anti-TPO, 11.8%; and AAT, 11.8%. Conclusions: Children and adolescents with T1DM have increased the prevalence of antithyroid and CD-related antibodies. The positivity for anti-GAD and antithyroid antibodies was less frequent than in other studies. The prevalence of anti-tTG antibodies was similar to the literature. |
| Databáze: | OpenAIRE |
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