Survival benefit of sphingosin-1-phosphate and receptors expressions in breast cancer patients

Autor: Yang Chang Wu, Hsueh Chou Lai, Wei Chun Chang, Li Ching Chu, Juan-Cheng Yang, Hsiao Ching Wang, Bi Hua Cheng, Fu Ju Lei, Pei Yin Liao, Wen Lung Ma
Rok vydání: 2018
Předmět:
0301 basic medicine
Cancer Research
Breast Neoplasms
Kaplan-Meier Estimate
Models
Biological
03 medical and health sciences
chemistry.chemical_compound
Breast cancer (BCA)
0302 clinical medicine
Breast cancer
Cell Movement
Sphingosine
Cell Line
Tumor
Gene expression
Biomarkers
Tumor
medicine
Adjuvant therapy
Humans
Radiology
Nuclear Medicine and imaging
skin and connective tissue diseases
Receptor
Sphingosine-1-Phosphate Receptors
S1PR1
Cell Proliferation
Original Research
Cell growth
Kinase
business.industry
Clinical Cancer Research
Lipid Metabolism
Prognosis
medicine.disease
Receptors
Lysosphingolipid
S1PR
Cell Transformation
Neoplastic
030104 developmental biology
Oncology
chemistry
030220 oncology & carcinogenesis
Cancer research
Sphingosine‐1‐Phosphate (S1P)
Female
lipids (amino acids
peptides
and proteins)
Lysophospholipids
business
Zdroj: Cancer Medicine
ISSN: 2045-7634
DOI: 10.1002/cam4.1609
Popis: Sphingosine‐1‐phosphate (S1P) is a bioactive lipid that exerts various pathophysiological functions through binding to its receptor family (S1PRs). Since first report of the breast cancer (BCA) promoting function by S1P production (through the function of sphingosine kinases) and S1P/S1PR signaling, their antagonists have never been successfully progress to clinics after three decades. Taking advantage of bioinformatics linking to gene expression to disease prognosis, we examined the impact of associated genes in BCA patients. We found high gene expressions involved in S1P anabolism suppressed disease progression of patients who are basal cell type BCA or receiving adjuvant therapy. In addition, S1PRs expression also suppressed disease progress of multiple categories of BCA patient progression. This result is contradictory to tumor promoter role of S1P/S1PRs which revealed in the literature. Further examination by directly adding S1P in BCA cells found a cell growth suppression function, which act via the expression of S1PR1. In conclusion, our study is the first evidence claiming a survival benefit function of S1P/S1PR signaling in BCA patients, which might explain the obstacle of relative antagonist apply in clinics.
Databáze: OpenAIRE
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