In vivo uptake of heterologous alphafetoprotein and serum albumin by ependymal cells of developing chick embryos

Autor:	Ricardo Moro, José Grunberg, Adriana Esteves, Walter Fielitz, José Uriel
Rok vydání:	1983
Předmět:	medicine.medical_specialty Ependymal Cell biology Albumin Serum albumin Heterologous Molecular biology Neuroepithelial cell Ovalbumin Endocrinology Developmental Neuroscience In vivo Internal medicine embryonic structures medicine biology.protein Receptor Developmental Biology
Zdroj:	International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2(2)
ISSN:	0736-5748
Popis:	The in vivo uptake by neuroepithelial cells of rat serum proteins injected into the mesencephalic cavity of developing chicken was demonstrated by immunohistochemical methods. It was found that 48 h after inoculation, rat alphafetoprotein (AFP) and serum albumin (SA) localize in the same places as do chicken AFP and SA. No labelling was present for rat or chicken IgG. We also present evidence showing that chicken ovalbumin, which is not normally found inside ependymal cells is not internalized even when injected into the cerebrospinal fluid at 30-fold its physiological concentration. The existence of transient specific receptors which could be responsible for this protein uptake is proposed. The possible implications in relation to developmental biology are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abc8bd1b0681546015889748cb96202 https://pubmed.ncbi.nlm.nih.gov/24873957 Zobrazit plný text záznamu Plný text