Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the re-fed rat
| Autor: | I. W. Harman, P. Strong, N. M. Clayton, A. K. Bahl, M. A. Trevethick |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Indazoles Indoles Leukotriene B4 Injections Subcutaneous Immunology Indomethacin Administration Oral Toxicology digestive system Pathogenesis chemistry.chemical_compound Internal medicine medicine Pyloric Antrum Animals Pharmacology (medical) Benzopyrans Stomach Ulcer Antrum Pharmacology Leukotriene business.industry Stomach digestive oral and skin physiology Antagonist medicine.disease digestive system diseases Neutrophilia Rats Microscopy Electron medicine.anatomical_structure Endocrinology chemistry Leukotriene Antagonists Female SRS-A medicine.symptom business Infiltration (medical) |
| Zdroj: | Agents and actions. 41(3-4) |
| ISSN: | 0065-4299 |
| Popis: | The potential involvement of leukotrienes in the pathogenesis of indomethacin-induced ulceration of the rat gastric antrum has been studied. Pretreatment with the leukotriene biosynthesis inhibitor, MK886 (30 mg/kg p.o.), inhibited the increases in blood and antral leukotriene B4 release ex vivo associated with the evolution of antral ulceration. Despite this, however, there was no significant reduction in either the area of antral ulceration, or in the associated blood neutrophilia and neutrophil infiltration into the gastric antrum. Similarly, pretreatment with the leukotriene B4 antagonist, SC41930 (50 mg/kg p.o.) or the peptidyl leukotriene antagonist ICI198,615 (50 mg/kg p.o.) did not inhibit the area of antral ulceration induced by indomethacin. Thus, in contrast to published reports studying fundic ulceration, our results suggest that leukotrienes do not play a major role either in the pathogenesis of indomethacin-induced ulceration of the rat gastric antrum or neutrophil infiltration into the damaged antrum. |
| Databáze: | OpenAIRE |
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