Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets
| Autor: | Gary Wong, Xiangguo Qiu, Zirui Zhang, Geoff Soule, Marc-Antoine de La Vega, Kevin Tierney, Kaylie Tran, Shihua He, Lisa Fernando |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine viruses 030106 microbiology Supplement Articles Viremia Disease Virus diseases Biology medicine.disease_cause Marburg virus Pathogenesis 03 medical and health sciences medicine Animals Immunology and Allergy Marburg Virus Disease Ebola virus Ferrets virus diseases medicine.disease Virology 3. Good health Disease Models Animal 030104 developmental biology Infectious Diseases biology.protein Female Disease Susceptibility Antibody Ravn virus |
| Zdroj: | The Journal of Infectious Diseases. 218:S471-S474 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiy245 |
| Popis: | Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections. |
| Databáze: | OpenAIRE |
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