Changes in Blood Selenium and Glutathione Concentrations and Glutathione Peroxidase Activity in Human Pregnancy
| Autor: | A Maciag, C Wardak, W Didkowski, E Marchaluk, B A Zachara |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Erythrocytes GPX3 Pregnancy Trimester Third chemistry.chemical_element Selenium chemistry.chemical_compound Pregnancy Internal medicine medicine Humans chemistry.chemical_classification Glutathione Peroxidase Labor Obstetric Chemistry Glutathione peroxidase Obstetrics and Gynecology Gestational age Glutathione medicine.disease Pregnancy Trimester First Red blood cell Endocrinology medicine.anatomical_structure Reproductive Medicine Pregnancy Trimester Second Gestation Female |
| Zdroj: | Gynecologic and Obstetric Investigation. 35:12-17 |
| ISSN: | 1423-002X 0378-7346 |
| Popis: | Whole-blood and plasma selenium (Se) concentrations, red blood cell and plasma glutathione peroxidase activities, and red blood cell glutathione concentrations were investigated in 49 healthy pregnant women. Mean whole-blood and red blood cell Se concentrations started to decline after the 16th week and plasma Se after the 26th week of pregnancy. The lowest values were noted just before delivery. Negative correlations were found between the gestational age and both whole-blood and plasma Se concentrations: (r = -0.560 (p < 0.001) and r = -0.553 (p < 0.001), respectively. Plasma and red blood cell glutathione peroxidase activities started to decrease after the 20th and 30th week of pregnancy, respectively, and before delivery were significantly lower (p < 0.001) than during the 10th week of pregnancy. The red blood cell glutathione concentration increased significantly just before delivery. These results seem to confirm the supposition that in pregnant women with low or even moderate blood Se concentrations the requirement for the element significantly increases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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