Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity
| Autor: | Allan I. Pack, Greg Maislin, S Juliusson, Bryndis Benediktsdottir, Erna S. Arnardottir, Richard Schwab, Brendan T. Keenan, Nicholas Jackson, Michael A. Grandner, Victoria M. Pak, Thorarinn Gislason, Karen L. Teff |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Polysomnography Intercellular Adhesion Molecule-1 Medicine (miscellaneous) Vascular Cell Adhesion Molecule-1 Article Body Mass Index Sleep Apnea Syndromes Internal medicine Cardiovascular Disease mental disorders Positive airway pressure medicine Humans Continuous positive airway pressure Obesity 2. Zero hunger Inflammation Sleep Apnea Obstructive Nutrition and Dietetics medicine.diagnostic_test Continuous Positive Airway Pressure Cell adhesion molecule business.industry Sleep apnea Adhesion respiratory system Middle Aged medicine.disease respiratory tract diseases 3. Good health Endocrinology Cardiovascular Diseases Disease Progression Female business Cell Adhesion Molecules |
| Zdroj: | International journal of obesity (2005) |
| ISSN: | 1476-5497 |
| Popis: | Background Elevated levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear. Objective Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes. Subjects/Methods The mean body mass index (BMI) was 32.4±5.1 kg/m2; subjects had moderate-to-severe OSA (apnea-hypopnea index = 45.0±20.2) and 79% were male. There were 177 full PAP users (≥4 hours/night and ≥20 of last 28 nights), 44 partial ( |
| Databáze: | OpenAIRE |
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