Fluoxetine Can Inhibit SARS-CoV-2 In Vitro
| Autor: | Ilka Engelmann, Famara Sane, Magloire Pandoua Nekoua, Arthur Dechaumes, Didier Hober, Sandrine Belouzard, Enagnon Kazali Alidjinou, Jean Dubuisson |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) animal structures viruses Serotonin reuptake inhibitor 030106 microbiology coronavirus medicine.disease_cause Microbiology Article Virus 03 medical and health sciences In vivo Virology medicine lcsh:QH301-705.5 Coronavirus Cytopathic effect Fluoxetine SARS-CoV-2 business.industry fungi fluoxetine virus diseases in vitro In vitro 030104 developmental biology lcsh:Biology (General) Vero cell business medicine.drug |
| Zdroj: | Microorganisms Volume 9 Issue 2 Microorganisms, Vol 9, Iss 339, p 339 (2021) |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms9020339 |
| Popis: | An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the coronavirus disease pandemic, drastically affecting global health and economy. Though the understanding of the disease has improved, fighting the virus remains challenging. One of the strategies is repurposing existing drugs as inhibitors of SARS-CoV-2. Fluoxetine (FLX), a selective serotonin reuptake inhibitor, reportedly inhibits the replication of RNA viruses, especially Coxsackieviruses B (CVB), such as CV-B4 in vitro and in vivo. Therefore, in this study, we investigated the in vitro antiviral activity of FLX against SARS-CoV-2 in a model of acute infection. When 10 μM of FLX was added to SARS-CoV-2-infected Vero E6 cells, the virus-induced cytopathic effect was not observed. In this model, the level of infectious particles in the supernatant was lower than that in controls. The level was below the limit of detection of the assay up to day 3 post-infection when FLX was administered before viral inoculation or simultaneously followed by daily inoculation. In conclusion, FLX can inhibit SARS-CoV-2 in vitro. Further studies are needed to investigate the potential value of FLX to combat SARS-CoV-2 infections, treat SARS-CoV-2-induced diseases, and explain the antiviral mechanism of this molecule to pave way for novel treatment strategies. |
| Databáze: | OpenAIRE |
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