Immunization with neural‐derived peptides increases neurogenesis in rats with chronic spinal cord injury

Autor:	Adrian Flores-Romero, Roxana Rodríguez-Barrera, Juan José Juárez-Vignon Whaley, Elisa García, Diego Incontri-Abraham, Ana María Fernández-Presas, Julián García-Sánchez, Ignacio Madrazo, Lisset Navarro‐Torres, Antonio Ibarra
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty Traumatic brain injury Neurogenesis INDP Rats Sprague-Dawley 03 medical and health sciences paraplegia 0302 clinical medicine Neurotrophic factors Physiology (medical) Internal medicine medicine Protective autoimmunity Animals Pharmacology (medical) Spinal cord injury Spinal Cord Injuries Pain Measurement Pharmacology sensitive recovery business.industry traumatic brain injury Neuropeptides Original Articles medicine.disease chronic stage Rats motor recovery Psychiatry and Mental health 030104 developmental biology Endocrinology Immunization SCI A91 peptide Female Original Article protective autoimmunity Tumor necrosis factor alpha Inflammation Mediators business Paraplegia 030217 neurology & neurosurgery
Zdroj:	CNS Neuroscience & Therapeutics
ISSN:	1755-5949 1755-5930
DOI:	10.1111/cns.13368
Popis:	Aims Immunization with neural‐derived peptides (INDP) has demonstrated to be a promising therapy to achieve a regenerative effect in the chronic phase of the spinal cord injury (SCI). Nevertheless, INDP‐induced neurogenic effects in the chronic stage of SCI have not been explored. Methods and Results In this study, we analyzed the effect of INDP on both motor and sensitive function recovery; afterward, we assessed neurogenesis and determined the production of cytokines (IL‐4, IL‐10, and TNF alpha) and neurotrophic factors (BDNF and GAP‐43). During the chronic stage of SCI, rats subjected to INDP showed a significant increase in both motor and sensitive recovery when compared to the control group. Moreover, we found a significant increase in neurogenesis, mainly at the central canal and at both the dorsal and ventral horns of INDP‐treated animals. Finally, INDP induced significant production of antiinflammatory and regeneration‐associated proteins in the chronic stages of SCI. Conclusions These findings suggest that INDP has a neurogenic effect that could improve motor and sensitive recovery in the chronic stage of SCI. Moreover, our results also envision the use of INDP as a possible therapeutic strategy for other trauma‐related disorders like traumatic brain injury.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab5dbb9f1e5ebe36110117f1631fab1 https://doi.org/10.1111/cns.13368 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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