Comparison of clinical outcome between stereotactic body radiotherapy and radiofrequency ablation for unresectable hepatocellular carcinoma
Autor: | Ren Ji, Kelvin K. Ng, Wenqi Chen, Weihong Yang, Hongtao Zhu, Tan-To Cheung, Chi-Leung Chiang, Tiffany C.L. Wong, Feng-Ming Kong, G. Wu, Chung-Mau Lo |
---|---|
Rok vydání: | 2022 |
Předmět: |
Adult
Aged 80 and over Male Radiofrequency Ablation Carcinoma Hepatocellular Liver Neoplasms Observational Study General Medicine Middle Aged body carcinoma Radiosurgery stereotactic surgical procedures operative Treatment Outcome hepatocellular Catheter Ablation Humans Female radiotherapy Aged Retrospective Studies Research Article |
Zdroj: | Medicine |
ISSN: | 1536-5964 0025-7974 |
Popis: | Stereotactic body radiotherapy (SBRT) is a novel noninvasive treatment for unresectable hepatocellular carcinoma (HCC). Whether its efficacy is comparable to radiofrequency ablation (RFA), a recommended therapy for unresectable HCC, is unknown. The present study aims to compare the clinical outcome between SBRT and RFA for patients with unresectable HCC. The clinical data of 60 patients with unresectable HCC from January 2018 to January 2021 were retrospectively reviewed. There were 22 cases treated by SBRT and 38 cases by RFA. The short-term and long-term clinical outcomes were compared. There was no significant difference in the baseline demographic characteristics between two groups. The complete remission rate at 3 months was comparable between SBRT group (81.8%) and RFA group (89.4%). Local tumor control rate was also similar between two groups (90.9% vs. 94.7%). There was no severe complication (grade IIIa or above) in both groups. The 1-year and 2-year overall survival rates were 88.2% and 85.7% in SBRT group and 100% and 75% in RFA group, respectively. There was no statistical significant difference between groups (P = .576). SBRT can achieve similar short and long-term clinical outcome as RFA for unresectable HCC. Future prospective clinical study is needed to justify its role in patients with HCC. |
Databáze: | OpenAIRE |
Externí odkaz: |