Programmes and principles in treatment of multidrug-resistant tuberculosis
| Autor: | Joia S. Mukherjee, Donna Barry, Mercedes C. Becerra, Kwonjune J. Seung, J. Keith Joseph, Sonya Shin, Jim Yong Kim, Paul Farmer, Adrienne R. Socci, Jennifer Furin, Felix A. Alcantara Viru, Jaime Bayona, Michael Rich, Mary C. Smith Fawzi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Tuberculosis National Health Programs Antitubercular Agents Disease Global Health Cohort Studies Pharmacotherapy Clinical Protocols Acquired immunodeficiency syndrome (AIDS) Drug Resistance Multiple Bacterial Tuberculosis Multidrug-Resistant medicine Global health Humans Intensive care medicine Antibiotics Antitubercular Tuberculosis Pulmonary Directly Observed Therapy Retrospective Studies Antibacterial agent business.industry Retrospective cohort study General Medicine medicine.disease Surgery Treatment Outcome Drug Therapy Combination business |
| Zdroj: | The Lancet. 363:474-481 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(04)15496-2 |
| Popis: | Summary Multidrug-resistant tuberculosis (MDR-TB) presents an increasing threat to global tuberculosis control. Many crucial management issues in MDR-TB treatment remain unanswered. We reviewed the existing scientific research on MDR-TB treatment, which consists entirely of retrospective cohort studies. Although direct comparisons of these studies are impossible, some insights can be gained: MDR-TB can and should be addressed therapeutically in resource-poor settings; starting of treatment early is crucial; aggressive treatment regimens and high-end dosing are recommended given the lower potency of second-line antituberculosis drugs; and strategies to improve treatment adherence, such as directly observed therapy, should be used. Opportunities to treat MDR-TB in developing countries are now possible through the Global Fund to Fight AIDS, TB, and Malaria, and the Green Light Committee for Access to Second-line Anti-tuberculosis Drugs. As treatment of MDR-TB becomes increasingly available in resource-poor areas, where it is needed most, further clinical and operational research is urgently needed to guide clinicians in the management of this disease. |
| Databáze: | OpenAIRE |
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