1H NMR as an analytical tool for the investigation of hydrolysis rates: a method for the rapid evaluation of the shelf-life of aqueous solutions of drugs with ester groups
| Autor: | Abu J. Ferdous, N. A. Dickinson, Roger D. Waigh |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Atropine
Hydrolysis constant Magnetic Resonance Spectroscopy Stereochemistry Inorganic chemistry Kinetics Pharmaceutical Science Hydrolysis symbols.namesake Reaction rate constant Drug Stability Pharmacology Arrhenius equation Aqueous solution Chemistry Temperature Esters Nuclear magnetic resonance spectroscopy Hydrogen-Ion Concentration Acetylcholine Solutions symbols Proton NMR Carbachol Procaine |
| Zdroj: | Journal of Pharmacy and Pharmacology. 43:860-862 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1991.tb03195.x |
| Popis: | The rate of hydrolysis of esters of primary and secondary alcohols can be determined quickly and easily by 1H NMR in aqueous solution, provided that the water signal is suppressed by the WATR (Water Attenuation by T2 Relaxation) method. To evaluate this approach, Arrhenius plots have been constructed for hydrolysis of acetylcholine, carbachol and atropine, and the effect of pH on the hydrolysis of procaine has been determined over a limited range. The results agree well with literature values for rate constants. |
| Databáze: | OpenAIRE |
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