Estrogen-Related Changes in Anterior Pituitary RNA Levels
| Autor: | J. A. Robinson, W. W. Leavitt |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Stimulation Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Estrus Anterior pituitary Pregnancy Internal medicine medicine Animals Castration Progesterone reproductive and urinary physiology Estrous cycle Estradiol urogenital system Proteins RNA DNA Stimulation Chemical Rats Endocrinology medicine.anatomical_structure chemistry Estrogen Pituitary Gland Ovariectomized rat Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental Biology and Medicine. 139:471-475 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-139-36166 |
| Popis: | SummaryHypophysial RNA in the female rat was found to fluctuate during the estrous cycle. Pituitary RNA levels were highest at proestrus and lowest at diestrus 1. The concentration of pituitary RNA and the RNA/DNA ration decreased after ovariectomy. Estradiol (1 μg/day) restored the hypophysial RNA/DNA ratio of ovariectomized rats to a level comparable to that of cyclic females, whereas progesterone (1 mg/day) had no effect. It was concluded that the elevation in pituitary RNA at proestrus can be attributed to estrogen stimulation and that a certain portion of pituitary RNA is estrogen dependent. |
| Databáze: | OpenAIRE |
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