Copper-Catalyzed Oxidative Cyclization/1,2-Amino Migration Cascade Reaction
| Autor: | Desuo Yang, Zheng-Hui Guan, Mi-Na Zhao, Zhi-Jing Zhang, Zhi-Hui Ren |
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| Rok vydání: | 2018 |
| Předmět: |
Reaction conditions
Oxidative cyclization Tandem 010405 organic chemistry Chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Oxygen 0104 chemical sciences Catalysis Cascade reaction Copper catalyzed Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 20:3088-3091 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.8b01139 |
| Popis: | A novel and efficient copper-catalyzed tandem oxidative cyclization/1,2-amino migration of readily available enamino esters for the synthesis of substituted pyrroles has been developed. In this reaction, one C–N bond was cleaved, and two new C–N bonds and one C(sp2)–C(sp2) bond were constructed in one pot. This catalytic system has the obvious advantages of mild reaction conditions and the use of oxygen as the oxidant. The reaction tolerates a wide range of functional groups and is a reliable method for the straightforward synthesis of valuable aminomethyl-substituted pyrroles in good yields. |
| Databáze: | OpenAIRE |
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