Microbial transformation of resibufogenin byCurvularia lunataAS 3.4381
| Autor: | Chao Wang, Rong-Gang Xi, Rong Lan, Jiang-Hao Sun, Gang Wang, Xiaobo Wang, Xiu-Lan Xin, Hua Li, Dong-Hai Su, Xiaokui Huo |
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| Rok vydání: | 2014 |
| Předmět: |
Curvularia lunata
Stereochemistry Pharmaceutical Science Microbial transformation Hydroxylation Redox Analytical Chemistry chemistry.chemical_compound Ascomycota Isomerism Biotransformation Drug Discovery Humans Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure Chemistry Organic Chemistry General Medicine Bufanolides Complementary and alternative medicine Molecular Medicine Female Drug Screening Assays Antitumor Isomerization HeLa Cells |
| Zdroj: | Journal of Asian Natural Products Research. 16:290-295 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2013.878332 |
| Popis: | In this paper, the microbial transformation of resibufogenin by Curvularia lunata AS 3.4381 was investigated, and four transformed products were isolated and characterized as 3-epi-resibufogenin (2), 12α-hydroxy-3-epi-resibufogenin (3), 12-oxo-16β-hydroxy-3-epi-resibufogenin (4), and 12β,15-epoxy-3-epi-bufalin-14,15-ene (5). Among them, 4 and 5 are new compounds, and isomerization, hydroxylation, and oxidation reactions in microbial transformation process were observed. Additionally, the cytotoxicities of transformed products (2-5) were also investigated. |
| Databáze: | OpenAIRE |
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