Immunogenicity of imported foot-and-mouth vaccines in different species in Mongolia
| Autor: | Gerelmaa Ulziibat, Georgina Limon, Ginette Wilsden, Batkhuyag Sandag, Anna B. Ludi, Nicholas A. Lyons, Ganzorig Basan, Donald P. King, Sodnomdarjaa Ruuragc, Clare Browning, Odonchimeg Maygmarsuren, Bodisaikhan Khishgee |
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| Rok vydání: | 2020 |
| Předmět: |
Veterinary medicine
medicine.medical_specialty Camelus 030231 tropical medicine Fmd virus Disease Biology Antibodies Viral Article 03 medical and health sciences Immunogenicity Vaccine 0302 clinical medicine Camels Epidemiology medicine Animals 030212 general & internal medicine Sheep General Veterinary General Immunology and Microbiology Foot-and-mouth disease business.industry Immunogenicity Vaccination Public Health Environmental and Occupational Health Viral Vaccines Mongolia medicine.disease Antibodies Neutralizing Infectious Diseases Foot-and-Mouth Disease Virus Foot-and-Mouth Disease Molecular Medicine Cattle Post-vaccination monitoring Livestock Viral disease business Foot (unit) |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| Popis: | Highlights • FMD vaccines were independently assessed using published international guidelines. • Highest titres were seen with oil-adjuvanted vaccines with a 2 dose primary course. • Lower titres were seen with aqueous vaccines requiring a boost after 3 months. • It is unknown how the lower titres observed in camels correlate with protection. • The results have important implications for vaccine policy in Mongolia. Foot-and-mouth disease (FMD) is a high impact viral disease of livestock for which vaccines are extensively used in control. Mongolia has regular incursions of FMD virus that are typically limited to the eastern region although large epidemics are occasionally reported in the normally disease-free western areas. Vaccines are imported and form an important component of the control strategy. In 2015, post-vaccination monitoring guidelines were published by the FAO-OIE recommending approaches for assessing the appropriateness of imported vaccines including small-scale immunogenicity studies. This study used these recommended approaches to guide the use of vaccine adjuvant type and the need for a one or two dose primary course in the national control programme considering cattle, sheep and Bactrian camels and also whether these vaccines were appropriate for the FMD virus lineages considered high risk to Mongolia (A/ASIA/Sea-97; O/SEA/Mya-98; O/ME-SA/PanAsia; O/ME-SA/Ind-2001). The results of these immunogenicity studies indicated that in cattle and sheep, oil-adjuvanted vaccines led to higher and more persistent neutralisation titres that were satisfactory against the target lineages if a two-dose primary course was utilised. In contrast, aqueous-adjuvanted vaccines were associated with lower titres that likely required a booster after 3 months. Levels of antibodies in Bactrian camels were significantly lower although it is unknown how these may correlate with protection under experimental or field exposure conditions. The results of this study have implications for vaccine policy in Mongolia and suggest further studies on the role of Bactrian camels in the epidemiology of FMD are necessary to indicate if further research on FMD vaccines are needed in this species. |
| Databáze: | OpenAIRE |
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