Suppression of Energy Intake by Intragastric l-Tryptophan in Lean and Obese Men: Relations with Appetite Perceptions and Circulating Cholecystokinin and Tryptophan
| Autor: | Sally D. Poppitt, Sina S Ullrich, Penelope C E Fitzgerald, Maryam Hajishafiee, Michael Horowitz, Kylie Lange, Christine Feinle-Bisset |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Food intake medicine.medical_specialty Maximum likelihood media_common.quotation_subject Medicine (miscellaneous) Appetite 030209 endocrinology & metabolism 03 medical and health sciences Neutral Amino Acids 0302 clinical medicine Primary outcome Double-Blind Method Internal medicine medicine Humans Obesity Cholecystokinin media_common 030109 nutrition & dietetics Nutrition and Dietetics business.industry Tryptophan medicine.disease Endocrinology business Energy Intake |
| Zdroj: | The Journal of nutrition. 151(10) |
| ISSN: | 1541-6100 |
| Popis: | BACKGROUND l-Tryptophan reduces energy intake in healthy men. The underlying mechanisms, including appetite, plasma cholecystokinin (CCK), tryptophan (Trp), and the ratio of Trp to large neutral amino acids (Trp:LNAAs ratio), and whether responses differ in lean and obese individuals, are uncertain. OBJECTIVES We evaluated the effects of intragastric Trp on energy intake (primary outcome) and their potential mechanisms, pre- and postmeal, in lean men and those with obesity. METHODS Twelve lean men [mean ± SD age: 30 ± 3 y; BMI (in kg/m2): 23 ± 1] and 13 men with obesity (mean ± SD age: 31 ± 3 y; BMI: 33 ± 1) received, on 3 separate occasions, in double-blind, randomized order, 3 g ("Trp-3") or 1.5 g ("Trp-1.5") Trp, or control ("C"), intragastrically, 30 min before a buffet-meal. Energy intake from the buffet-meal, hunger, fullness, and plasma CCK and amino acid concentrations were measured in response to Trp alone and for 2 h postmeal. Data were analyzed using maximum likelihood mixed-effects models, with treatment, group, and treatment-by-group interaction as fixed effects. RESULTS Trp alone increased plasma CCK, Trp, and the Trp:LNAAs ratio (all P |
| Databáze: | OpenAIRE |
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