The Relationship Between Serum Endocan Level and Aortic Elastic Properties in Patients With Newly Diagnosed Essential Hypertension

Autor: Erdoğan Sökmen, Murat Erer, Cahit Uçar, Serkan Sivri, Mustafa Çelik, Rukiye Nar
Přispěvatelé: Kırşehir Ahi Evran Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri, Kardiyoloji ABD
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
aortic stiffness
Blood Pressure
Newly diagnosed
030204 cardiovascular system & hematology
Essential hypertension
Aorta/*diagnostic imaging/physiopathology
Biomarkers/blood
Case-Control Studies
Cross-Sectional Studies
Echocardiography
Doppler
Pulsed
Elasticity
Essential Hypertension/blood/*diagnostic imaging/physiopathology
Female
Humans
Middle Aged
Neoplasm Proteins/*blood
Predictive Value of Tests
Prognosis
Prospective Studies
Proteoglycans/*blood
Up-Regulation
Vascular Stiffness
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
In patient
Endothelial dysfunction
Aortic strain
Aorta
Surrogate endpoint
business.industry
medicine.disease
Neoplasm Proteins
030220 oncology & carcinogenesis
Cardiology
cardiovascular system
Population study
Aortic stiffness
Proteoglycans
serum endocan level
Essential Hypertension
Cardiology and Cardiovascular Medicine
business
Biomarkers
Popis: WOS: 000473199100010 PubMed ID: 30630336 Endothelial dysfunction plays role in the generation of both essential hypertension (EH) and aortic stiffness. We evaluated the relationship between serum endocan level and aortic elastic properties (AEPs) assessed with the aortic strain, aortic distensibility, and aortic stiffness index by echocardiography. Newly diagnosed EH patients (n = 67) and controls (n = 70) were included in the study. The EH group was subdivided into stage 1 and 2 EH groups. A higher endocan level was found in the EH group, compared to the controls (34.2 +/- 13.0 vs 24.1 +/- 7.3 ng/mL, respectively, P < .001). All the AEP parameters were worse in the EH group, compared to the controls. Further, endocan levels correlated with aortic distensibility (r = -0.305, P < .001) and aortic strain (r = -0.181, P = .038), but not with aortic stiffness index (r = 0.162, P = .064) in the whole study population. Aortic elastic properties deteriorate and serum endocan level increases in patients with EH. Moreover, serum endocan level shows a correlation with deteriorated AEPs, and hence may a surrogate marker of escalating aortic stiffness in patients with newly diagnosed EH. Ahi Evran University Board of Scientific Research Projects [TIP.A3.16.003] The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by Ahi Evran University Board of Scientific Research Projects (Grant Number: TIP.A3.16.003).
Databáze: OpenAIRE
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