Differential Roles of Ventral and Dorsal Streams for Conceptual and Production-Related Components of Tool Use in Acute Stroke Patients
| Autor: | Irina Mader, Andrea Dressing, Christoph P. Kaller, Roza M. Umarova, Markus Martin, Lena Beume, Tobias Bormann, Vera M. Ludwig, Charlotte S. M. Schmidt, Michel Rijntjes, Dorothee Kümmerer, Cornelius Weiller |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Apraxias Cognitive Neuroscience Concept Formation Context (language use) Intraparietal sulcus Intention computer.software_genre Apraxia 050105 experimental psychology Temporal lobe 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Supramarginal gyrus Voxel medicine Humans 0501 psychology and cognitive sciences Stroke Aged Aged 80 and over Neuronal Plasticity 05 social sciences Inferior parietal lobule Middle Aged medicine.disease Temporal Lobe Female Psychology computer Neuroscience 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | Cerebral cortex (New York, N.Y. : 1991). 26(9) |
| ISSN: | 1460-2199 |
| Popis: | Impaired tool use despite preserved basic motor functions occurs after stroke in the context of apraxia, a cognitive motor disorder. To elucidate the neuroanatomical underpinnings of different tool use deficits, prospective behavioral assessments of 136 acute left-hemisphere stroke patients were combined with lesion delineation on magnetic resonance imaging (MRI) images for voxel-based lesion-symptom mapping. Deficits affecting both the selection of the appropriate recipient for a given tool (ToolSelect, e.g., choosing the nail for the hammer), and the performance of the typical tool-associated action (ToolUse, e.g., hammering in the nail) were associated with ventro-dorsal stream lesions, particularly within inferior parietal lobule. However, ToolSelect compared with ToolUse deficits were specifically related to damage within ventral stream regions including anterior temporal lobe. Additional retrospective error dichotomization based on the videotaped performances of ToolUse revealed that spatio-temporal errors (movement errors) were mainly caused by inferior parietal damage adjacent to the intraparietal sulcus while content errors, that is, perplexity, unrecognizable, or semantically incorrect movements, resulted from lesions within supramarginal gyrus and superior temporal lobe. In summary, our results suggest that in the use of tools, conceptual and production-related aspects can be differentiated and are implemented in anatomically distinct streams. |
| Databáze: | OpenAIRE |
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