Topical nonsteroidal anti-inflammatory drugs as adjuvant therapy in the prevention of macular edema after cataract surgery
| Autor: | Tersa Centoducati, Carmela Palmisano, Giovanni Alessio, Nicola Cardascia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Administration Topical medicine.medical_treatment Intraocular lens Cataract Extraction Nepafenac Macular Edema 03 medical and health sciences Postoperative Complications 0302 clinical medicine Diclofenac Drug Therapy Ophthalmology medicine Humans Macula Lutea Glucocorticoids Macular edema Dexamethasone Aged Retrospective Studies Aged 80 and over business.industry Anti-Inflammatory Agents Non-Steroidal Phacoemulsification Middle Aged medicine.disease Surgery Treatment Outcome Anesthesia 030221 ophthalmology & optometry Female Bromfenac sense organs Netilmicin business Tomography Optical Coherence 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | International Ophthalmology. 37:1127-1131 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/s10792-016-0374-5 |
| Popis: | The purpose of the study was to assess adjuvant treatment with topical nonsteroidal anti-inflammatory drugs (NSAIDs) (0.9 % bromfenac, 0.1 % nepafenac, 0.5 % indomethacin, or 0.1 % diclofenac) in addition to topical steroidal treatment with 0.1 % dexamethasone and 0.3 % netilmicin for prevention of cystoid macular edema (CME) after uneventful small incision cataract extraction with foldable intraocular lens (IOL) implantation. Institute of Ophthalmology, Department of Scienze Mediche di Base, Neuroscienze ed Organi di Senso, Aldo Moro University, Policlinico Consorziale di Bari, Bari, Italy. A retrospective 6-month single center study. Patients were divided into groups according to treatment with topical drugs for 2 weeks, after phacoemulsification with foldable IOL implantation. CME incidence was evaluated by assessing retinal foveal thickness changes using spectral domain optical coherence tomography. All patients were treated with a fixed combination of dexamethasone and netilmicin, and some patients were additionally treated with NSAIDs (bromfenac, nepafenac, indomethacin, or diclofenac). Fourteen patients were treated with bromfenac, 15 with nepafenac, 12 with indomethacin, and 14 with diclofenac; ten patients were treated with dexamethasone and netilmicin alone. At the end of the follow-up, macular thickness, evaluated at 1-week post-surgery, was reduced only in the group treated with nepafenac (−1.3 %, p = 0.048), was increased in the group treated with dexamethasone and netilmicin alone (+4.3 %, p = 0.04), and did not change in the groups treated with bromfenac (−1.1 %, p = 0.3), indomethacin (+0.1 %, p = 0.19), or diclofenac (+1.2 %, p = 0.74). There were no side effects in any group. Topical treatment with nepafenac, bromfenac, and indomethacin enhanced the efficacy of steroids to reduce postoperative macular edema. Diclofenac did not improve steroids efficacy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink