Cost-Effectiveness of Enoxaparin as Thromboprophylaxis in Acutely Ill Medical Patients in Spain
| Autor: | V Nadipelli, C. Rubio-Terrés, C. Suarez, J Kosa, F. Antoñanzas Villar, Mjc Nuijten |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Cost effectiveness Cost-Benefit Analysis MEDLINE Asymptomatic Recurrence Risk Factors Medical illness Thromboembolism Humans Medicine In patient Enoxaparin Intensive care medicine cost-effectiveness health care economics and organizations Clinical Trials as Topic Cost–benefit analysis business.industry Health Policy Decision Trees Public Health Environmental and Occupational Health Anticoagulants Markov model Markov Chains Spain Acute Disease medicine.symptom business Venous thromboembolism Resource utilization |
| Zdroj: | Value in Health. 6:126-136 |
| ISSN: | 1098-3015 |
| DOI: | 10.1046/j.1524-4733.2003.00210.x |
| Popis: | Objective The objective of this study was to determine the cost-effectiveness of thromboprophylaxis with enoxaparin versus no thromboprophylaxis in patients with acute medical illness in Spain from the society perspective. Methods Markov process analysis techniques were used to model the health economic outcomes. Clinical data were derived mainly from the MEDENOX trial, while health-care utilization was derived from Delphi panels. Results An analysis over the MEDENOX trial period shows that the cost per event avoided is ¤432, while the cost per life saved is ¤1527. The cost per event includes all medical resource utilization costs associated with the event. The lifetime model, which assumes no higher risk for recurrence of venous thromboembolism (VTE) and mortality in asymptomatic patients, shows that the use of enoxaparin leads a cost per event avoided of ¤270 and cost per life-year gained of ¤71. If the lifetime model assumes a higher risk for recurrence of VTE in asymptomatic patients, enoxaparin is dominant over no thromboprophylaxis. Conclusion The results showed that the favorable clinical benefit of enoxaparin as thromboprophylaxis in patients with acute medical illness, which was observed in the MEDENOX trial, results in a positive health economic benefit in both the short term and the long term in the health-care setting of Spain. |
| Databáze: | OpenAIRE |
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