Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis
| Autor: | Xinxin Long, Fangli Lu, Xin-zhuan Su, Nelson Siukei Lam |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Paragonimus westermani 030231 tropical medicine Helminthiasis 03 medical and health sciences 0302 clinical medicine Helminths parasitic diseases medicine Animals Humans Heterophyes heterophyes Opisthorchis viverrini Artemisinin Schistosoma Pharmacology Anthelmintics biology Fasciola biology.organism_classification Virology Artemisinins 030104 developmental biology medicine.drug Toxocara canis |
| Zdroj: | Pharmacological research. 133 |
| ISSN: | 1096-1186 |
| Popis: | The World Health Organization estimated that more than 1.5 billion people are infected with soil-transmitted helminths globally, and foodborne trematodiases in humans cause ∼2 million life-years lost to disability and death worldwide every year. Investment in prevention, treatment, and awareness of helminth infections and discovery of new, safe, effective, and affordable anti-helminth drugs are urgently needed. Artemisinin (ART) and its derivatives have been widely used to treat malaria and other protozoan infections; they also possess activities against helminths. So far, many papers on ART and its derivatives against schistosomal infections have been reported and reviewed. This review attempts to summarize recent advances in the uses of ART and its derivatives to treat infections of helminth parasites other than Schistosoma spp. in both humans and animals, including nematodes (Toxocara canis, Trichinella spiralis, Haemonchus contortus, Meloidogyne spp., Globodera rostochiensis, and Xiphinema index), cestodes (Echinococcus spp. and Taenia crassiceps), trematodes (Echinostoma spp., Fasciola spp., Clonorchis sinensis, Opisthorchis viverrini, Paragonimus westermani, Heterophyes heterophyes, and Paramphistomum microbothrium), and monogenea parasites (Dactylogyrus and Gyrodactylus). We concluded that ART and its derivatives are potentially effective drugs for treating various helminthic diseases of public health significance. |
| Databáze: | OpenAIRE |
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