| Autor: |
Margalida Torrens-Mas, Catalina M. Perelló-Reus, Neus Trias-Ferrer, Lesly Ibargüen-González, Catalina Crespí, Aina Maria Galmes-Panades, Cayetano Navas-Enamorado, Andres Sanchez-Polo, Javier Piérola-Lopetegui, Luis Masmiquel, Lorenzo Socias Crespi, Carles Barcelo, Marta Gonzalez-Freire |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Cellular and Infection Microbiology. 12 |
| ISSN: |
2235-2988 |
| DOI: |
10.3389/fcimb.2022.942951 |
| Popis: |
Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and healthy control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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