| Popis: |
Compare outcomes of Melody valve to mechanical mitral valve replacement (MVR) for young children.Children who underwent Melody MVR from 2014-2020 were case-matched to mechanical MVR patients. Transplant-free survival and cumulative incidence of re-intervention were compared. A sub-analysis was performed for infants1 year of age (n=9 Melody MVRs and their matches).Twelve children underwent Melody MVR. Two (17%) children salvaged from mechanical support died. Five (50%) of 10 survivors had subsequent MVR. At 1 and 3 years, transplant free survival (Melody: 83%, 83%; mechanical: 83%, 67%; p=0.180) and re-intervention (Melody: 9%, 39%; mechanical: 0%, 18% p=0.18) were equivalent between groups. For children1 year of age, Melody MVR had a modest survival benefit (Melody: 89%, 89%; mechanical: 80%, 60%; p=0.046) while rate of re-intervention remained equivalent (Melody: 13%, 32%; mechanical: 0%, 22%; p=0.32).For patients1 year old, Melody MVR offers a promising alternative and is a reasonable bridge to mechanical MVR which can be performed safely at an older age. Further studies are necessary to corroborate these findings. |
