The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases

Autor:	James O'Connell, Tom Crabbe, Gillian Murphy, Sarojani Angal, Andrew J. P. Docherty
Rok vydání:	1992
Předmět:	Metalloproteinase Cdna cloning Chemistry Molecular Sequence Data Metalloendopeptidases Bioengineering Matrix metalloproteinase Extracellular Matrix Biochemistry Tissue damage Cancer research Gelatinase Animals Humans Amino Acid Sequence Cloning Molecular Connective Tissue Diseases Biotechnology
Zdroj:	Trends in biotechnology. 10(6)
ISSN:	0167-7799
Popis:	Uncontrolled matrix metalloproteinase activity is thought to be a cause of the tissue damage observed in many disease processes. None of the drugs currently in use can prevent tissue destruction, and strategies for the development of synthetic inhibitors have been hampered by a poor understanding of the biochemistry of matrix metalloproteinases. Recent cDNA cloning efforts and characterization of recombinant human matrix metalloproteinases have permitted structure-function analysis of the enzymes and their inhibitors. Progress in this area should help indicate a route to rational strategies for designing lead therapeutic compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa88d67f319ba96566a10653be4b1db https://pubmed.ncbi.nlm.nih.gov/1368394 Zobrazit plný text záznamu