Chronic Blockade of Phosphatidylinositol 3-Kinase in the Nucleus Tractus Solitarii Is Prohypertensive in the Spontaneously Hypertensive Rat
| Autor: | Jasenka Zubcevic, Julian F. R. Paton, Hidefumi Waki, Mohan K. Raizada, Alexandra Gampel, Carlos Diez-Freire |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Blood Pressure Baroreflex Rats Inbred WKY Article Phosphatidylinositol 3-Kinases Spontaneously hypertensive rat Heart Rate Internal medicine Rats Inbred SHR Internal Medicine medicine Solitary Nucleus Animals Homeostasis cardiovascular diseases RNA Messenger business.industry Solitary nucleus Neurogenic hypertension Rostral ventrolateral medulla Rats Disease Models Animal Protein Subunits Blood pressure Endocrinology medicine.anatomical_structure Gene Expression Regulation Hypertension business Nucleus circulatory and respiratory physiology Signal Transduction |
| Popis: | Phosphatidylinositol 3-kinase (PI3K) within brain stem neurons has been implicated in hypertension in the spontaneously hypertensive rat (SHR). Previously, we demonstrated elevated expression of PI3K subunits in rostral ventrolateral medulla and paraventricular nucleus of SHRs compared with Wistar-Kyoto rats. Here, we considered expression levels of PI3K in the nucleus tractus solitarii, a pivotal region in reflex regulation of arterial pressure, and determined its functional role for arterial pressure homeostasis in SHRs and Wistar-Kyoto rats. We found elevated mRNA levels of p110β and p110δ catalytic PI3K subunits in the nucleus tractus solitarii of adult (12 to 14 weeks old) SHRs relative to the age-matched Wistar-Kyoto rats (fold differences relative to β-actin: 1.7±0.2 versus 1.01±0.08 for p110β, n=6, P P P P P |
| Databáze: | OpenAIRE |
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