Correlations between diffusion-weighted imaging and breast cancer biomarkers
Autor: | Riccardo Ponzone, Daniele Regge, Stefania Redana, Veronica Deantoni, Filippo Montemurro, Massimo Aglietta, Laura Martincich, Franziska Kubatzki, Ilaria Bertotto, Ivana Sarotto, Valentina Rossi, Michele Liotti |
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Rok vydání: | 2012 |
Předmět: |
Adult
medicine.medical_specialty Receptor ErbB-2 diffusion-weighted imaging Statistics as Topic Breast Neoplasms Sensitivity and Specificity breast cancer Breast cancer Biomarkers Tumor medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging cardiovascular diseases Aged Neuroradiology business.industry Ultrasound Reproducibility of Results General Medicine Middle Aged medicine.disease body regions Diffusion Magnetic Resonance Imaging Ki-67 Antigen Receptors Estrogen Female Radiology business Diffusion MRI |
Zdroj: | European Radiology. 22:1519-1528 |
ISSN: | 1432-1084 0938-7994 |
Popis: | We evaluated whether the apparent diffusion coefficient (ADC) provided by diffusion-weighted imaging (DWI) varies according to biological features in breast cancer.DWI was performed in 190 patients undergoing dynamic contrast-enhanced magnetic resonance imaging (MRI) for local staging. For each of the 192 index cancers we studied the correlation between ADC and classical histopathological and immunohistochemical breast tumour features (size, histological type, grade, oestrogen receptor [ER] and Ki-67 expression, HER2 status). ADC was compared with immunohistochemical surrogates of the intrinsic subtypes (Luminal A; Luminal B; HER2-enriched; triple-negative). Correlations were analysed using the Mann-Whitney U and Kruskal-Wallis H tests.A weak, statistically significant correlation was observed between ADC values and the percentage of ER-positive cells (-0.168, P = 0.020). Median ADC values were significantly higher in ER-negative than in ER-positive tumours (1.110 vs 1.050 × 10(-3) mm(2)/s, P = 0.015). HER2-enriched tumours had the highest median ADC value (1.190 × 10(-3) mm(2)/s, range 0.950-2.090). Multiple comparisons showed that this value was significantly higher than that of Luminal A (1.025 × 10(-3) mm(2)/s [0.700-1.340], P = 0.004) and Luminal B/HER2-negative (1.060 × 10(-3) mm(2)/s [0.470-2.420], P = 0.008) tumours. A trend towards statistical significance (P = 0.018) was seen with Luminal B/HER2-positive tumours.ADC values vary significantly according to biological tumour features, suggesting that cancer heterogeneity influences imaging parameters.DWI may identify biological heterogeneity of breast neoplasms. • ADC values vary significantly according to biological features of breast cancer. • Compared with other types, HER2-enriched tumours show highest median ADC value. • Knowledge of biological heterogeneity of breast neoplasm may improve imaging interpretation. |
Databáze: | OpenAIRE |
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