Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration
| Autor: | Allison M. Burns, Johannes Gräff |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
biology medicine.drug_class General Neuroscience Histone deacetylase inhibitor Acetylation Cognition Epigenesis Genetic Histone Deacetylase Inhibitors Histones 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Histone biology.protein medicine Epigenetics Mode of action Priming (psychology) Neuroscience 030217 neurology & neurosurgery Epigenesis |
| Zdroj: | Current Opinion in Neurobiology |
| ISSN: | 0959-4388 |
| Popis: | Multiple studies have found that increasing histone acetylation by means of histone deacetylase inhibitor (HDACi) treatment can ameliorate memory and rescue cognitive impairments, but their mode of action is not fully understood. In particular, it is unclear how HDACis, applied systemically and devoid of genomic target selectivity, would specifically improve memory-related molecular processes. One theory for such specificity is called cognitive epigenetic priming (CEP), according to which HDACis promote memory by facilitating the expression of neuroplasticity-related genes that have been stimulated by learning itself. In this review, we summarize the experimental evidence in support of CEP, describe newly discovered off-target effects of HDACis and highlight similarities between drug-induced and naturally occurring CEP. Understanding the underlying mechanisms of CEP is important in light of the preclinical premise of HDACis as cognitive enhancers. |
| Databáze: | OpenAIRE |
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