Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses
| Autor: | Tiago Ruivo Correia, Ilídio J. Correia, Álvaro M. F. De Carvalho, Patrícia Alves, Bernardo Paiva Antunes, Paula Ferreira |
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| Přispěvatelé: | uBibliorum |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Biocompatibility lcsh:Biotechnology Voice prosthesis 02 engineering and technology 01 natural sciences chemistry.chemical_compound Silicone lcsh:TP248.13-248.65 0103 physical sciences lcsh:TA401-492 General Materials Science Composite material 10.13 Polydimethylsiloxane 010304 chemical physics Cell adhesion Adhesion 021001 nanoscience & nanotechnology Membrane chemistry Plasma surface modification 30.10 Papers Surface modification lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Biomedical engineering Protein adsorption |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP Science and Technology of Advanced Materials, Vol 14, Iss 5, p 055006 (2013) Science and Technology of Advanced Materials Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) |
| Popis: | The voice is produced by the vibration of vocal cords which are located in the larynx. Therefore, one of the major consequences for patients subjected to laryngectomy is losing their voice. In these cases, a synthetic one-way valve set (voice prosthesis) can be implanted in order to allow restoration of speech. Most voice prostheses are produced with silicone-based materials such as polydimethylsiloxane (PDMS). This material has excellent properties, such as optical transparency, chemical and biological inertness, non-toxicity, permeability to gases and excellent mechanical resistance that are fundamental for its application in the biomedical field. However, PDMS is very hydrophobic and this property causes protein adsorption which is followed by microbial adhesion and biofilm formation. To overcome these problems, surface modification of materials has been proposed in this study. A commercial silicone elastomer, SylgardTM 184 was used to prepare membranes whose surface was modified by grafting 2-hydroxyethylmethacrylate and methacrylic acid by low-pressure plasma treatment. The hydrophilicity, hydrophobic recovery and surface energy of the produced materials were determined. Furthermore, the cytotoxicity and antibacterial activity of the materials were also assessed. The results obtained revealed that the PDMS surface modification performed did not affect the material's biocompatibility, but decreased their hydrophobic character and bacterial adhesion and growth on its surface. |
| Databáze: | OpenAIRE |
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