Interactions between NCR+ILC3s and the Microbiome in the Airways Shape Asthma Severity
| Autor: | Kyoung Hee Sohn, Jihyun Kim, Hye Ryun Kang, Jaehyun Park, Min Gyung Baek, Hana Yi, Yong-Soo Bae, Jongho Ham, Siyoung Yang, Sang Heon Cho, Young Chan Kim, Doo Hyun Chung, Hyeyoung Kim, Sungmi Choi, Sungho Won |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Lung microbiome
Immunology Alpha (ethology) Innate lymphoid cells Disease immune system diseases medicine Immunology and Allergy Microbiome Asthma Lung business.industry Microbiota Innate lymphoid cell Host-microbial interaction Sputum respiratory system medicine.disease respiratory tract diseases Infectious Diseases medicine.anatomical_structure Original Article medicine.symptom business |
| Zdroj: | Immune Network |
| ISSN: | 2092-6685 1598-2629 |
| Popis: | Asthma is a heterogeneous disease whose development is shaped by a variety of environmental and genetic factors. While several recent studies suggest that microbial dysbiosis in the gut may promote asthma, little is known about the relationship between the recently discovered lung microbiome and asthma. Innate lymphoid cells (ILCs) have also been shown recently to participate in asthma. To investigate the relationship between the lung microbiome, ILCs, and asthma, we recruited 23 healthy controls (HC), 42 patients with non-severe asthma, and 32 patients with severe asthma. Flow cytometry analysis showed severe asthma associated with fewer natural cytotoxicity receptor (NCR)+ILC3s in the lung. Similar changes in other ILC subsets, macrophages, and monocytes were not observed. The asthma patients did not differ from the HC in terms of the alpha and beta-diversity of the lung and gut microbiomes. However, lung function correlated positively with both NCR+ILC3 frequencies and microbial diversity in the lung. Sputum NCR+ILC3 frequencies correlated positively with lung microbiome diversity in the HC, but this relationship was inversed in severe asthma. Together, these data suggest that airway NCR+ILC3s may contribute to a healthy commensal diversity and normal lung function. |
| Databáze: | OpenAIRE |
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