Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
| Autor: | Zbyněk Tüdös, Rohit Philip Thomas, Lucia Veverková, Paulína Szász, Igor Hartmann, Jozef Skarda, František Hruška |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
accessory spleen
Pathology medicine.medical_specialty Dorsal mesentery Adrenal Gland Neoplasm 030232 urology & nephrology Spleen Case Report Accessory spleen splenosis Metastasis spleno-renal fusion 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma spleno-gonadal fusion medicine spleno-adrenal fusion business.industry General Medicine medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Splenic Tissue adrenal gland neoplasms splenic heterotopy Medicine Pancreas business |
| Zdroj: | Open Medicine Open Medicine, Vol 16, Iss 1, Pp 087-094 (2020) |
| ISSN: | 2391-5463 |
| Popis: | Foci of splenic tissue separated from the spleen can occur as a congenital anomaly. Isolated nodules of splenic tissue are called accessory spleens or spleniculli. However, nodules of splenic tissue can merge with other organs during embryonic development, in which case we speak of spleno-visceral fusions: most often, they merge with the tail of the pancreas (thus forming spleno-pancreatic fusion or an intrapancreatic accessory spleen), with the reproductive gland (i.e., spleno-gonadal fusion), or with the kidney (i.e., spleno-renal fusion). Our case report describes the fusion of heterotopic splenic tissue with the right adrenal gland, which was misinterpreted as a metastasis of a renal cell carcinoma. To the best of our knowledge, this is the first reported case of spleno-adrenal fusion. Spleno-visceral fusions usually represent asymptomatic conditions; their main clinical significance lies in the confusion they cause and its misinterpretation as tumors of other organs. We believe that the cause of retroperitoneal spleno-visceral fusions is the anomalous migration of splenic cells along the dorsal mesentery to the urogenital ridge, together with primitive germ cells, at the end of the fifth week and during the sixth week of embryonic age. This theory explains the possible origin of spleno-visceral fusions, their different frequency of occurrence, and the predominance of findings on the left side. |
| Databáze: | OpenAIRE |
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