Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells
| Autor: | Byung Sun Yoo, Han Bit Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
SH-SY5Y neuroblastoma cell SH-SY5Y Neurite Tissue transglutaminase Health Toxicology and Mutagenesis Pharmacology toxicology Neurite outgrowth GAP-43 Propolis Biology Toxicology Neuroblastoma cell 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Biochemistry biology.protein TGase Original Article Erratum 030217 neurology & neurosurgery |
| Zdroj: | Toxicological Research |
| ISSN: | 2234-2753 1976-8257 |
| Popis: | Propolis is a multicomponent, active, complex resinous substance collected by honeybees from a variety of plant sources. We have studied the effect of propolis on neurite outgrowth of SH-SY5Y human neuroblastoma cells induced to differentiate by all-trans-retinoic acid (RA). Propolis, at a concentration of 3 μg/mL, had no significant effect on the viability of differentiating SH-SY5Y cells. However, the neurite outgrowth of the differentiating SH-SY5Y cells treated with propolis (0.3~3 μg/mL) for 48 hr was significantly inhibited in a dose-dependent manner. Treatment of RA-stimulated differentiating SH-SY5Y cells with 0.3 to 3 μg/mL propolis resulted in decreased level of transglutaminase and 43-kDa growth-associated protein (GAP-43) in a dose-dependent manner. The results indicate that propolis is able to inhibit neurite outgrowth of differentiating SH-SY5Y cells. |
| Databáze: | OpenAIRE |
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